| Title | Year | Genre |
|---|---|---|
| Space War | ???? | Shooter |
| Space War II | 1994 | Shooter |
| SpaceAce | ???? | Arcade |
| Spaceball | ???? | Breakout |
| SpaceBall 2000 | ???? | Breakout |
| Spacecutter | ???? | Action |
| Spaceport | ???? | Shooter |
| Spacer | ???? | Action |
| Spaceship X325L | 1993 | Arcade |
| Spacewrecked | ???? | Adventure |
| Spanish Tutor, The | ???? | Educational |
| Spanish, French, German, Italian Tutor | 1990 | Educational |
| Spatial Hyperdrive | ???? | Arcade |
| Specials Forces | ???? | Action |
| Speed | ???? | Arcade |
| Speed Buggy | ???? | Racing |
| Speed Racer FX | ???? | Action |
| Speed Worm | ???? | Shooter |
| Speedball | ???? | Sports |
| Speedball 2 | ???? | Sports |
| Speedboat Assassins | ???? | Racing |
| Speedrunner | ???? | Arcade |
| Speedtris | 1994 | Puzzle |
| Speedway Manager | 1993 | Management |
| Speedway Manager 2 | ???? | Management |
| Speedway Nostalgia - The League Title Chasing Game for the 1960's | ???? | Management |
| Speleologie en Aveugle | 2020 | Adventure |
| Spell Book | ???? | Educational |
| Spell Bound | ???? | Arcade |
| Spell-A-Fari | ???? | Educational |
| Spellbound Dizzy & Dizzy Panic | ???? | Compilation |
| Spellbound! | ???? | Educational |
| Spellbreaker | ???? | Adventure |
| Spellfire the Sorcerer | ???? | Action |
| Speris Legacy | ???? | RPG |
| Sperrgebiet | 1992 | Arcade |
| Spherical | ???? | Arcade |
| Spherical Worlds | ???? | Action |
| Sphericule | ???? | Arcade |
| Spheroid | 2022 | Arcade |
| Spiderman | ???? | Action |
| Spiderman 2 | ???? | Action |
| Spiderman 3 | ???? | Action |
| Spidertronic | ???? | Arcade |
| Spielend Lernen 2 - Bis 6 Jahre | ???? | Educational |
| Spike in Transylvania | ???? | Adventure |
| SpikeDislike | 2022 | Arcade |
| Spin Brix | ???? | Puzzle |
| Spindizzy Worlds | ???? | Arcade |
| Spinworld | ???? | Action |
