| Title | Year | Genre |
|---|---|---|
| Space Heat | 1995 | Shooter |
| Space Hulk | ???? | Action |
| Space Invaders | 2021 | Shooter |
| Space Invasion | 1998 | Shooter |
| Space Invasion II | 1994 | Shooter |
| Space Job | ???? | Adventure |
| Space Max | ???? | Adventure |
| Space Pack | 1997 | Action |
| Space Panic | ???? | Arcade |
| Space Pilot 89 | ???? | Shooter |
| Space Pong | 2022 | Breakout |
| Space Power | 1993 | Action |
| Space Quest | ???? | Adventure |
| Space Quest - The Sarien Encounter | ???? | Adventure |
| Space Quest I - Roger Wilco in the Sarien Encounter | ???? | Adventure |
| Space Quest II | ???? | Adventure |
| Space Quest III | ???? | Adventure |
| Space Quest IV | ???? | Adventure |
| Space Racer | ???? | Racing |
| Space Ranger | ???? | Action |
| Space Rescue | 1992 | Shooter |
| Space Rogue | ???? | Spaceship |
| Space Spuds | ???? | Action |
| Space Station | ???? | Action |
| Space Taxi | ???? | Arcade |
| Space Taxi 3 | 1994 | Arcade |
| Space War | ???? | Shooter |
| Space War II | 1994 | Shooter |
| SpaceAce | ???? | Arcade |
| Spaceball | ???? | Breakout |
| SpaceBall 2000 | ???? | Breakout |
| Spacecutter | ???? | Action |
| Spaceport | ???? | Shooter |
| Spacer | ???? | Action |
| Spaceship X325L | 1993 | Arcade |
| Spacewrecked | ???? | Adventure |
| Spanish Tutor, The | ???? | Educational |
| Spanish, French, German, Italian Tutor | 1990 | Educational |
| Spatial Hyperdrive | ???? | Arcade |
| Specials Forces | ???? | Action |
| Speed | ???? | Arcade |
| Speed Buggy | ???? | Racing |
| Speed Racer FX | ???? | Action |
| Speed Worm | ???? | Shooter |
| Speedball | ???? | Sports |
| Speedball 2 | ???? | Sports |
| Speedboat Assassins | ???? | Racing |
| Speedrunner | ???? | Arcade |
| Speedtris | 1994 | Puzzle |
| Speedway Manager | 1993 | Management |
